Will have to be PC/C++/OpenGL to work unless you are not using MacOS (booting into XP on Mac which sort of works).
Maya will work fine on Mac, as will Zbrush.
Dunno about PhysX for Mac, prob not. (Havok is available to licensees for Mac)
The dev env is just GCC / Xcode etc (http://developer.apple.com/tools/xcode/), very straightforward.